Bacterial Pathogens Associated with Hidradenitis Suppurativa, France

نویسندگان

  • Hélène Guet-Revillet
  • Hélène Coignard-Biehler
  • Jean-Philippe Jais
  • Gilles Quesne
  • Eric Frapy
  • Sylvain Poirée
  • Anne-Sophie Le Guern
  • Anne Le Flèche-Matéos
  • Alain Hovnanian
  • Paul-Henry Consigny
  • Olivier Lortholary
  • Xavier Nassif
  • Aude Nassif
  • Olivier Join-Lambert
چکیده

Hidradenitis suppurativa (HS) is a skin disease characterized by recurrent nodules or abscesses and chronic suppurating lesions. In the absence of clear pathophysiology, HS is considered to be an inflammatory disease and has no satisfactory medical treatment. Recently, prolonged antimicrobial treatments were shown to improve or resolve HS lesions. We prospectively studied the microbiology of 102 HS lesions sampled from 82 patients using prolonged bacterial cultures and bacterial metagenomics on 6 samples. Staphylococcus lugdunensis was cultured as a unique or predominant isolate from 58% of HS nodules and abscesses, and a polymicrobial anaerobic microflora comprising strict anaerobes, milleri group streptococci, and actinomycetes was found in 24% of abscesses or nodules and in 87% of chronic suppurating lesions. These data show that bacteria known to cause soft tissue and skin infections are associated with HS lesions. Whether these pathogens are the cause of the lesions or are secondary infectious agents, these findings support targeted antimicrobial treatment of HS.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Microbial profile and antibiotic susceptibility of bacteria isolated from patients with hidradenitis suppurativa

Background: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease of unknown etiology. There is evidence that bacteria may contribute to initiating the inflammatory response in HS patients. To date, data on bacteria found in HS lesions and their resistance rates are rare. Methods: The results of bacterial cultures and antibiotic susceptibility of the isolated bacteria obtained fr...

متن کامل

Hidradenitis suppurativa.

Hidradenitis suppurativa is a chronic, relapsing, inflammatory disease process that primarily involves the axilla and/or inguinal region and does not manifest itself until after puberty. Typically, the process begins as a local occlusive disease of a sweat gland; secondary bacterial infection then occurs. The early stages of hidradenitis suppurativa are usually managed by the dermatologist. Onc...

متن کامل

Wide Excision with Secondary Intention Healing: Proper Procedure for Nonextensive Gluteal Hidradenitis Suppurativa

luteal hidradenitis suppurativa (HS) is an acute, subacute, or chronic infection that affects the sudoriparous, apocrine, eccrine, or pilosebaceous apparatus of the affected area. Although its pathophysiology is poorly understood, it is generally believed that obstruction of the apocrine pores results in glandular dilatation and bacterial superinfection, with subsequent gland rupture disseminat...

متن کامل

Arthritis associated with hidradenitis suppurativa.

OBJECTIVE To review the presentation and clinical findings of arthritis associated with hidradenitis suppurativa. METHOD Medical records from the rheumatology clinics of two major teaching hospitals were reviewed for arthritis and hidradenitis suppurativa. The nine patient records fulfilling these criteria were reviewed and compared with 20 previous reports. RESULTS AND CONCLUSION The arthr...

متن کامل

Altered innate and adaptive immune responses in patients with hidradenitis suppurativa.

BACKGROUND The clinical improvement of hidradenitis suppurativa reported in a small number of patients with antitumour necrosis factor (anti-TNF)-alpha therapies supports the hypothesis for an altered immune response in these patients. OBJECTIVES To evaluate the state of the innate and adaptive immune responses in patients with hidradenitis suppurativa. METHODS Fifty-three patients and six ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 20  شماره 

صفحات  -

تاریخ انتشار 2014